Image
Interactive Showcase

Updates on the Diagnosis and Management of Alzheimer's Disease

Meeting Slides

Patient Resources

Effective Communication in Alzheimer's Disease

Finding Information and Support

Tools

Montreal Cognitive Assessment

This is a 10-minute cognitive screening tool designed to assist physicians in the detection of mild cognitive impairment. A screening score less than 26 yields a positive screen for mild cognitive impairment. It has very good sensitivity and specificity.

Nasreddine ZS, et al. J Am Geriatr Soc. 2005;53:695-699.

Alzheimer’s Disease Assessment Scale-Cognition (ADAS-Cog)

The ADAS-Cog is designed to measure the severity of cognitive impairment symptoms during the assessment of Alzheimer’s disease. It is recommended for second stage or a more detailed evaluation.

Rosen WG, et al.Am J Psychiatry. 1984;141:1356-1364.

Modified Mini Mental Exam (3MS)

The mini mental exam is a brief test of cognitive function and current mental state. It is commonly used as a screening tool to test for dementia. The modified mini mental exam version is designed to sample a broader variety of cognitive functions and enhance the reliability and validity of the scores.

Teng EL, Che HC. J Clin Psychiatry. 1987;48:314-318.

Guidelines

International Work Group (IWG) Criteria for the Diagnosis of Alzheimer Disease

The IWG guidelines allow for the highly specific diagnosis of Alzheimer’s disease (AD). They identify a unified spectrum of 3 stages, from at-risk state asymptomatic to symptomatic prodromal AD and AD dementia. Biomarker confirmation is required for the diagnosis of AD at any clinical stage.

Cummings JL, et al. Med Clin N Am. 2013;97:363-368.

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association (NIA-AA) workgroups on diagnostic guidelines for Alzheimer’s disease

The NIA-AA working group put forth criteria for the diagnosis of symptomatic mild cognitive impairment. The core clinical criteria is intended for use by healthcare providers without access to advanced imaging techniques or cerebrospinal fluid analysis.

Albert MS, et al. Alzheimers Dement. 2011;7:270-279.

Suggested Readings

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease

Albert MS, et al. Alzheimers Dement. 2011;7:270-279.

Therapeutic application of melatonin in mild cognitive impairment

Cardinali DP, et al. Am J Neurodegener Dis. 2012;1:280-291.

Alzheimer’s disease: strategies for disease modification

Citron M. Nat Rev Drug Discov. 2010;9:387-398.

International Work Group Criteria for the Diagnosis of Alzheimer Disease

Cummings JL, et al. Med Clin N Am. 2013;97:363-368.

Amyloid-beta assessed by florbetapir F-18 PET and 18-month cognitive decline: A multicenter study

Doraiswamy PM, et al. Neurology. 2012;79:1636-1644.

Cerebrospinal Fluid tau/Beta Amyloid 42 Ratio as a Prediction of Cognitive Decline in Nondemented Older Adults

Fagan AM, et al. Arch Neurol. 2007;64:343-349.

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging and the Alzheimer’s Association workgroup

McKhann GM, et al. Alzheimers Dement. 2011;7:263-269.

Practical Guidelines for the Recognition and Diagnosis of Dementia

Galvin JE, Sadowsky CH. J Am Board Fam Med. 2012;25:367-382.

Multi-modal techniques for diagnosis and prognosis of Alzheimer’s disease

Perrin RJ, et al. Nature. 2009;461:916-922.

Snapshot:pathology of Alzheimer’s disease

Selkoe DJ. Cell. 2013;154:468-468.e1.

Toward deļ¬ning the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging and the Alzheimer’s Association workgroup

Sperling RA, et al. Alzheimers Dement. 2011;7:280-292.

Comparison of International Working Group criteria and National Institute on Aging-Alzheimer’s Association criteria for Alzheimer’s disease

Visser PJ, et al. Alzheimers Dement. 2012;8:560-563.