In Practice/In Context™

HCV Updates and Insights

Clinical Practice Guidelines

Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living With HIV. 

US Department of Health and Human Services, 2017 (last updated October 2018).

Evaluation and Management of Chronic Hepatitis C Virus (HCV) Infection.

Federal Bureau of Prisons Clinical Guidance. 2018.

HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C.

American Association for the Study of Liver Diseases/Infectious Diseases Society of America (AASLD/IDSA), 2017.

Clinical Resources

Harm Reduction Coalition.


HEP Drug Interactions.

University of Liverpool, 2019.

Opioid Overdose Prevention Toolkit.

Substance Abuse and Mental Health Services Administration (SAMHSA).

Suggested Readings

Direct-acting antivirals improve access to care and cure for patients with HIV and chronic HCV infection.

Collins LF, et al. Open Forum Infect Dis. 2018;5(1):ofx264.

Opportunities for treatment of the hepatitis C virus-infected patient with chronic kidney disease.

Ladino M, et al. World J Hepatol. 2017;9(19):833-839.

Universal opt-out screening for hepatitis C virus (HCV) within correctional facilities is an effective intervention to improve public health.

Morris MD, et al. Int J Prison Health. 2017;13(3-4):192-199.

Retention in buprenorphine treatment is associated with improved HCV care outcomes.

Norton BL, et al. J Subst Abuse Treat. 2017;75:38-42.

The syndemic of opioid misuse, overdose, HCV, and HIV: structural-level causes and interventions.

Perlman DC, Jordan AE. Curr HIV/AIDS Rep. 2018;15(2):96-112.

Primary care for persons who inject drugs.

Visconti AJ, et al. Am Fam Physician. 2019;99(2):109-116.

Risk factors for hepatitis C virus reinfection after sustained virologic response in patients coinfected with HIV.

Young J, et al. Clin Infect Dis. 2017;64(9):1154-1162.

Action and Advocacy


Health literacy and liver disease.

Gulati R, et al. Clin Liver Dis. 2018;11(2):48-51.

Hepatitis Education Project.

The Hepatitis Education Project provides support, education, advocacy, and direct services for people affected by hepatitis, and works to raise hepatitis awareness among patients, medical providers, and the general public.

National Hepatitis Corrections Network.

The National Hepatitis Corrections Network (NHCN) supports a public health approach to hepatitis education, prevention, testing, and treatment in prisons and jails.

Project ECHO (Extension for Community Healthcare Outcomes).

Project ECHO is a collaborative, telecommunications-based model of medical education and care management designed to train primary care clinicians to provide specialty care in rural and underserved areas.


Drug purchasing strategies to treat people with hepatitis C in the criminal justice system.

Akiyama MJ, et al. Am J Public Health. 2018;108(5):607-608.

Center for Health Law and Policy Innovation of Harvard Law School (CHLPI) and National Viral Hepatitis Roundtable (NVHR).

Together, CHLPI and NVHR continue to play a pivotal role in removing Medicaid restrictions on HCV treatment. An interactive map allows you to see each state’s Medicaid restrictions. Last updated November 2018.

Expansion of treatment for hepatitis C virus infection by task shifting to community-based nonspecialist providers: a nonrandomized clinical trial.

Kattakuzhy S, et al. Ann Intern Med. 2017;167(5):311-318.


North American Syringe Exchange Network (NASEN).

NASEN provides a directory of syringe exchange programs that can be located by zip code, landmark, city, or state.

SAMHSA: Behavioral Health Treatment Services Locator.

SAMHSA provides confidential and anonymous information on substance abuse and mental health treatment facilities throughout the United States and its territories.

SAMHSA: Medication-Assisted Treatment (MAT) Support Organizations.

SAMHSA provides numerous links to nonprofit associations, federal agencies, and patient groups that offer support for providers of medication-assisted treatment (MAT), as well as their patients and families.

Patient Resources

Hepatitis C Information Center

American Liver Foundation, 2018.
The American Liver Foundation’s Hepatitis C Information Center website is a dedicated online information and resource center created in support of individuals impacted by HCV infection.

Project Inform

Project Inform provides up-to-date information to help people living with HIV and HCV make the best choices regarding their treatment and care.


Complete List of References Associated With Figure Titled Real-World Evidence.

Conway B, et al. American Association for the Study of Liver Diseases. The Liver Meeting® 2016 – AASLD. November 11−15, 2016; Boston, MA. Poster 1992.
Dore GJ, et al. Ann Intern Med. 2016;165(9):625-634.
Drugs@FDA. 2018.
Grebely J, et al. Clin Infect Dis. 2016;63(11):1405-1411.
Grebely J, et al. Clin Infect Dis. 2016;63(11):1479-1481.
Grebely J, et al. J Hepatol. 2017;66:S513-S514.
Kiser JJ. Top Antivir Med. 2016;24(3):106-110.
Naggie SD, et al. N Engl J Med. 2015;373(8):705-713.
Osinusi A, et al. JAMA. 2015;313(12):1232-1239.
Puoti M, et al. J Hepatol. 2018;69(2):293-300.
Rockstroh JK, et al. Clin Infect Dis. 2018;67(7):1010-1017.
Rockstroh JK, et al. Lancet HIV. 2015;2(8):e319-e327.
Rockstroh JK. European Association for the Study of the Liver. The International Liver Congress™ − EASL 2017. April 19-23, 2017; Amsterdam, The Netherlands.
Sulkowski MS, et al. JAMA. 2015;313(12):1223-1231.
Wyles D, et al. Clin Infect Dis. 2017;65(1):6-12.
Zeuzem S, et al. Ann Intern Med. 2015;163(1):1-13.

HCV Updates and Insights

Realities, Challenges, and Opportunities to Improve Care

Relevant Resources

PrEP for Your Patients’ Needs

The PCPs Role in Preventing HIV

Value-Based HIV Formularies

Optimizing Use of Clinical Evidence & Pharmacoeconomic Models in Managed Care

Targeting NASH

Advances in the Diagnosis and Treatment of Nonalcoholic Steatohepatitis

Hepatitis C is Curable

Got it? Treat it!

Real-World Issues in HIV Prevention & Treatment

The Critical Role of the Community Pharmacist


Bringing Local Communities Together to Eliminate Coinfection Through Knowledge and Partnerships.

Evolving Models of HIV Care

Volume 1: Rapid ART Initiation: A New Addition to the HIV-Care Tool Box

The Nexus of NASH and Type 2 Diabetes Mellitus

The Emerging Role of the Diabetologist

Updates in HCV Screening and Treatment

Key Issues Impacting OB/GYN Practice

The Big Picture of IBD

An Interactive Experience Highlighting Recent Clinical Advances

Clinical Issues in Chronic Liver Disease

Hot Topics in HBV, HCV, and NASH

The Changing Landscape of IBD

Emerging Concepts in Patient Management

The Big (& Small) Picture of Nonalcoholic Steatohepatitis

Building Your Understanding to Combat a Growing Problem

Evolving Models of HIV Care

Volume II: Expanding Evidence for the Role of Rapid ART Initiation in HIV Practice

Assessing Your Patients for HCV and HIV

Why It Matters in OB/GYN Practice Today

HIV as a Chronic Disease

A Treater’s Guide to Optimizing Care in the Aging Patient with Comorbidities

The Pursuit of Hepatitis C Elimination

How the Pharmacist Can Make a Difference

Trends in Infectious Diseases: Updates on Treatment & Prevention Strategies for HIV and HCV

Understanding the Growing Syndemic — Opioids, HCV, and HIV

Trends and Updates in IBD

Appraising the Therapeutic Armamentarium in Moderate and Severe Disease

Stepping Up to the Challenge

The PCP’s Role in HCV Elimination

The Changing Landscape of HIV Prevention

What the Pharmacist Needs to Know about PrEP

Evolving Models of HIV Care (Volume 3)

The Rapid ART Standard of Care: From Evidence to Healthcare Equity

HIV Updates for Pharmacy Practice

Maximizing Your Role to Impact Patient Outcomes


Building Bridges to Reach People Who Inject Drugs With the Goal to Eliminate HCV

Case Challenges in HIV Medicine

Benefits, Barriers, & Best Practices in an Advancing Field

Challenges and Opportunities in HIV

Practical Solutions Across the Spectrum of Care

A Critical Appraisal of Non-Invasive Technologies in NASH

Informing the Future of NASH Diagnosis and Assessment

Expanding HIV Prevention in Colorado—and Nationwide

A PEP/PrEP Training Guide for Pharmacists

Setting a Course for the Optimal Management of IBD

An Interactive Learning Experience

Optimizing Advanced Therapies in Ulcerative Colitis: Is Your Practice Up to Date?

A Focus on Clinical Evidence and Guideline Recommendations

Treating Hepatitis C in the Primary Care Setting

A Critical Step Toward HCV Elimination

Honing Clinical Skills in HIV Treatment

Considering the Patient, the Provider, and the Science

Hot Topics in HCV

A Multidisciplinary Online Mini-Curriculum

IBD Journal Club:

Volume 1: A Guided Tour of the Evidence Driving Selection of First-line Advanced Therapies in Moderate to Severe IBD

Clinical Issues in COVID-19

Debates and Discussions about Monoclonal Antibody Therapies

Minimizing Patient Risks From COVID-19

An Update on Monoclonal Antibody Therapies

Treating Hepatitis C in the Primary Care Setting

Establishing Clinical Readiness Through Mentored Learning

Finding the Path in Eosinophilic Esophagitis

Interdisciplinary Strategies for Adult and Pediatric Patients

Answering the Call

Interdisciplinary Management of Eosinophilic Esophagitis and Hereditary Angioedema

Putting a Spotlight on Systemic Mastocytosis

A Multidisciplinary Look at Early Diagnosis and Management

Clinical Updates in COVID-19

Recent Developments in Anti-SARS-CoV-2 Monoclonal Antibodies for Treatment

Is It Systemic Mastocytosis?

Best Practices for Diagnosis and Management

Monoclonal Antibodies for COVID-19

An Update on Best Practices

Monoclonal Antibodies for COVID-19

New Avenues to Pre-Exposure Prophylaxis

Virologic Failure in HIV

An Updated Clinician’s Guide to Assessment and Management

Applying HIV Advances in Practice

What the Pharmacist Needs to Know

Buffing Up on New and Emerging ART

A Look at the Changing HIV Playing Field

Pharmacy PrEP Education

A “How To” Series Spanning Policy to Practice


Building Bridges to Reach People who Inject Drugs with the Goal of Employing PrEP for HIV Prevention

Long-Acting Injectable PrEP:

Bringing HIV Prevention to a New Level

PrEParing to End the Epidemic

Optimizing HIV Prevention in Primary Care

A Call to Action

Monoclonal Antibodies for the Prevention and Treatment of COVID-19

What’s Next

Exploring New Treatment Avenues in Nonadvanced Systemic Mastocytosis

Answers to Everyday Practice Challenges in HIV Medicine

A Phone-a-Friend CME Series – Volume 2

What’s New in the Management of COVID-19

Incorporating New Data and Updated Guidelines Into Daily Practice

Strengthening Your COVID-19 Management Technique

Exercising Best Practices for Hospitalized Patients