A Clinician’s Guide to HCV Treatment in the Primary Care Setting
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Clinical Practice Guidelines
CDC Recommendations for Hepatitis C Screening Among Adults in the United States.
Centers for Disease Control and Prevention (CDC). Last reviewed July 2020.
HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C.
American Association for the Study of Liver Diseases (AASLD)/Infectious Diseases Society of America (IDSA), Last updated March 2021.
Simplified HCV Treatment Algorithm for Treatment-Naive Adults Without Cirrhosis.
American Association for the Study of Liver Diseases (AASLD)/Infectious Diseases Society of America (IDSA). Last updated August 2020.
Clinical Resources
Recommended Testing Sequence for Identifying Current HCV Infection
Center for Disease Control and Prevention; Morbidity and Mortality Weekly Report (MMWR)
Hepatitis C Online Tools and Calculators: APRI
Hepatitis C Online: University of Washington
Hepatitis C Online Tools and Calculators: FIB-4
Hepatitis C Online: University of Washington
HEP Drug Interactions
University of Liverpool.
Action and Advocacy: National HCV Resources
Center for Health Law and Policy Innovation (CHLPI)
CHLPI advocates for legal, regulatory, and policy reforms to improve the health of underserved populations. It has played a pivotal role in removing Medicaid restrictions on HCV treatment.
Hepatitis Education Project (HEP)
HEP provides support, education, advocacy, and direct services for people affected by hepatitis, and works to raise hepatitis awareness among patients, medical providers, and the general public.
National Viral Hepatitis Roundtable
National Viral Hepatitis Roundtable (NVHR) is a coalition working together to eliminate hepatitis B and C in the U.S. It offers practical online resources for practice management.
Substance Abuse and Mental Health Services Administration (SAMHSA): Locator Map
SAMHSA provides an interactive national map that facilitates identification of local resources and services for substance use and mental health disorders.
National Harm Reduction Coalition
The National Harm Reduction Coalition builds evidence-based strategies with and for people who use drugs.
Patient Resources
Hepatitis C Information Center
American Liver Foundation.
The American Liver Foundation’s Hepatitis C Information Center website is a dedicated online information and resource center created in support of individuals impacted by HCV infection.
Hepatitis C Questions and Answers for the Public
Centers for Disease Control and Prevention (CDC). Last reviewed July 2020.
The CDC is a division within the US Department of Health and Human Services (DHHS), the principal agency for protecting the health of all Americans. This patient-directed website addresses basics across the HCV clinical continuum.
Suggested Readings
Expansion of treatment for hepatitis C virus infection by task shifting to community-based nonspecialist providers: a nonrandomized clinical trial.
Kattakuzhy S, et al. Ann Intern Med. 2017;167(5):311-318.
Patient centeredness in hepatitis C direct-acting antiviral treatment delivery to people who inject drugs: a scoping review.
Abdelwadoud M, et al. Patient. 2021;14(5):471-484.
Association between opioid agonist therapy and testing, treatment uptake, and treatment outcomes for hepatitis C infection among people who inject drugs: a systematic review and meta-analysis.
Grebely J, et al. Clin Infect Dis. 2021;73(1):e107-e118.
Minimal monitoring of treatment for hepatitis C virus infection.
Sulkowski MS. Gastroenterol Hepatol. 2021;17(5):230-232.
The curing regimens of HCV: a SWOT analysis.
Cornberg M, Manns MP. Antivir Ther. 2022;27(2):13596535211072672.
Therapy of chronic viral hepatitis: the light at the end of the tunnel?
Saracco GM, et al. Biomedicines. 2022;10(3):534.
Real-world effectiveness and safety of sofosbuvir/velpatasvir and ledipasvir/sofosbuvir hepatitis C treatment in a single centre in Germany.
Buggisch P, et al. PLOS ONE. 2019;14(4):e0214795.
Real-world effectiveness and safety of glecaprevir/pibrentasvir for the treatment of chronic hepatitis C infection: data from the German hepatitis C registry.
Berg T, et al. Aliment Pharmacol Ther. 2019;49(8):1052-1059.
Key elements on the pathway to HCV elimination: lessons learned from the AASLD HCV special interest group 2020.
Feld JJ, Ward JW. Hepatol Commun. 2021;5(6):911-922.
A Multimedia eHealth Source™ Educational Initiative
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