A Clinician’s Guide to HCV Treatment in the Primary Care Setting
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Clinical Practice Guidelines
CDC Recommendations for Hepatitis C Screening Among Adults in the United States.
Centers for Disease Control and Prevention (CDC). Last reviewed July 2020.
HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C.
American Association for the Study of Liver Diseases (AASLD)/Infectious Diseases Society of America (IDSA), Last updated March 2021.
Simplified HCV Treatment Algorithm for Treatment-Naive Adults Without Cirrhosis.
American Association for the Study of Liver Diseases (AASLD)/Infectious Diseases Society of America (IDSA). Last updated August 2020.
Clinical Resources
Recommended Testing Sequence for Identifying Current HCV Infection
Center for Disease Control and Prevention; Morbidity and Mortality Weekly Report (MMWR)
Hepatitis C Online Tools and Calculators: APRI
Hepatitis C Online: University of Washington
Hepatitis C Online Tools and Calculators: FIB-4
Hepatitis C Online: University of Washington
HEP Drug Interactions
University of Liverpool.
Action and Advocacy: National HCV Resources
Center for Health Law and Policy Innovation (CHLPI)
CHLPI advocates for legal, regulatory, and policy reforms to improve the health of underserved populations. It has played a pivotal role in removing Medicaid restrictions on HCV treatment.
Hepatitis Education Project (HEP)
HEP provides support, education, advocacy, and direct services for people affected by hepatitis, and works to raise hepatitis awareness among patients, medical providers, and the general public.
National Viral Hepatitis Roundtable
National Viral Hepatitis Roundtable (NVHR) is a coalition working together to eliminate hepatitis B and C in the U.S. It offers practical online resources for practice management.
Substance Abuse and Mental Health Services Administration (SAMHSA): Locator Map
SAMHSA provides an interactive national map that facilitates identification of local resources and services for substance use and mental health disorders.
National Harm Reduction Coalition
The National Harm Reduction Coalition builds evidence-based strategies with and for people who use drugs.
Patient Resources
Hepatitis C Information Center
American Liver Foundation.
The American Liver Foundation’s Hepatitis C Information Center website is a dedicated online information and resource center created in support of individuals impacted by HCV infection.
Hepatitis C Questions and Answers for the Public
Centers for Disease Control and Prevention (CDC). Last reviewed July 2020.
The CDC is a division within the US Department of Health and Human Services (DHHS), the principal agency for protecting the health of all Americans. This patient-directed website addresses basics across the HCV clinical continuum.
Suggested Readings
Expansion of treatment for hepatitis C virus infection by task shifting to community-based nonspecialist providers: a nonrandomized clinical trial.
Kattakuzhy S, et al. Ann Intern Med. 2017;167(5):311-318.
Patient centeredness in hepatitis C direct-acting antiviral treatment delivery to people who inject drugs: a scoping review.
Abdelwadoud M, et al. Patient. 2021;14(5):471-484.
Association between opioid agonist therapy and testing, treatment uptake, and treatment outcomes for hepatitis C infection among people who inject drugs: a systematic review and meta-analysis.
Grebely J, et al. Clin Infect Dis. 2021;73(1):e107-e118.
Minimal monitoring of treatment for hepatitis C virus infection.
Sulkowski MS. Gastroenterol Hepatol. 2021;17(5):230-232.
The curing regimens of HCV: a SWOT analysis.
Cornberg M, Manns MP. Antivir Ther. 2022;27(2):13596535211072672.
Therapy of chronic viral hepatitis: the light at the end of the tunnel?
Saracco GM, et al. Biomedicines. 2022;10(3):534.
Real-world effectiveness and safety of sofosbuvir/velpatasvir and ledipasvir/sofosbuvir hepatitis C treatment in a single centre in Germany.
Buggisch P, et al. PLOS ONE. 2019;14(4):e0214795.
Real-world effectiveness and safety of glecaprevir/pibrentasvir for the treatment of chronic hepatitis C infection: data from the German hepatitis C registry.
Berg T, et al. Aliment Pharmacol Ther. 2019;49(8):1052-1059.
Key elements on the pathway to HCV elimination: lessons learned from the AASLD HCV special interest group 2020.
Feld JJ, Ward JW. Hepatol Commun. 2021;5(6):911-922.
A Multimedia eHealth Source™ Educational Initiative
Relevant Resources
Overcoming Pain and Gastrointestinal Distress to Improve Patient Outcomes
Evidence-Based Strategies for Improved Patient Outcomes
Proactive Diagnosis and Targeted Management
Differential Diagnosis and Comprehensive Management Strategies
Optimizing Maintenance Therapy Across Healthcare Settings
Evolving Strategies for Diagnosis and Long-Term Management
Consensus and Controversies for Responsible Opioid Prescribing
Best Practices in Combination Therapy
Evolving Approaches to Insulin Based Therapy
Improving Outcomes for Patients with COPD
New Strategies for Insulin Replacement Therapy
Clinical Updates in LDL-C Management
Improving Comprehensive Patient Care
Identifying Patients and Tailoring Therapy
Collaborative Approaches to Guideline-Concordant Patient Care
New Strategies for Individualizing Long-term Care
A Focus on Patients With Opioid-Induced Constipation
Consensus and Controversies Across the Spectrum of Patient Presentations
Evolving Treatment Algorithms and Expert Perspectives on Biosimilars
Evolving Best Practices to Optimize Outcomes
The PCPs Role in Preventing HIV
The PCP’s Role in Timely Recognition and Referral
What Do You Know About PrEP?
Optimizing Use of Clinical Evidence & Pharmacoeconomic Models in Managed Care
Advances in the Diagnosis and Treatment of Nonalcoholic Steatohepatitis
What Do You Know About PrEP?
Got it? Treat it!
The Critical Role of the Community Pharmacist
Bringing Local Communities Together to Eliminate Coinfection Through Knowledge and Partnerships.
Volume 1: Rapid ART Initiation: A New Addition to the HIV-Care Tool Box
The Emerging Role of the Diabetologist
Differential Diagnosis, Multidisciplinary Management, and Patient Engagement
Key Issues Impacting OB/GYN Practice
An Interactive Experience Highlighting Recent Clinical Advances
Hot Topics in HBV, HCV, and NASH
Emerging Concepts in Patient Management
Building Your Understanding to Combat a Growing Problem
Volume II: Expanding Evidence for the Role of Rapid ART Initiation in HIV Practice
Why It Matters in OB/GYN Practice Today
Improving Patient Outcomes Through Shared Clinical Decision Making
A Treater’s Guide to Optimizing Care in the Aging Patient with Comorbidities
How the Pharmacist Can Make a Difference
Mechanistic Insights and Evolving Treatment Options
HIV Can Be Prevented— Are You Doing Your Part?
Rapid Start ART — A New Model for HIV Care
Clinical Resource Center
Understanding the Growing Syndemic — Opioids, HCV, and HIV
Appraising the Therapeutic Armamentarium in Moderate and Severe Disease
A Case-Based Conversation on Managing Asthma and Chronic Rhinosinusitis With Nasal Polyposis
The Clinical and Utilization Benefits of Exacerbation Prevention
A PrEP Primer
A Foundation for Managed Care
Cardiovascular and Renal Outcomes With SGLT2 Inhibitors
Best Practices for Primary Care
New Paths to Chronic Pain Management
The PCP’s Role in HCV Elimination
What the Pharmacist Needs to Know about PrEP
The Rapid ART Standard of Care: From Evidence to Healthcare Equity
Unlocking Novel Paths to Patient Care
Maximizing Your Role to Impact Patient Outcomes
Building Bridges to Reach People Who Inject Drugs With the Goal to Eliminate HCV
Benefits, Barriers, & Best Practices in an Advancing Field
Practical Solutions Across the Spectrum of Care
A PEP/PrEP Training Guide for Pharmacists
The Increasing Role of JAK Inhibitors
An Interactive Learning Experience
A Focus on Clinical Evidence and Guideline Recommendations
Preventing COPD Exacerbations to Improve Outcomes
A Critical Step Toward HCV Elimination
Considering the Patient, the Provider, and the Science
A Multidisciplinary Online Mini-Curriculum
A Whole Patient Case Series
Volume 1: A Guided Tour of the Evidence Driving Selection of First-line Advanced Therapies in Moderate to Severe IBD
Debates and Discussions about Monoclonal Antibody Therapies
An Update on Monoclonal Antibody Therapies
Getting on the Fast Track to Identify AxSpA
Establishing Clinical Readiness Through Mentored Learning
Interdisciplinary Strategies for Adult and Pediatric Patients
Interdisciplinary Management of Eosinophilic Esophagitis and Hereditary Angioedema
Reducing LDL-C and a Lifetime of Cardiovascular Risk
Updates, Clinical Scenarios, and Future Directions
A Multidisciplinary Look at Early Diagnosis and Management
Recent Developments in Anti-SARS-CoV-2 Monoclonal Antibodies for Treatment
Best Practices for Diagnosis and Management
An Update on Best Practices
New Avenues to Pre-Exposure Prophylaxis
Are You Aware of New Blood-Based Multi-Cancer Screening Tools
An Updated Clinician’s Guide to Assessment and Management
What the Pharmacist Needs to Know
A Look at the Changing HIV Playing Field
A “How To” Series Spanning Policy to Practice
Test Your Mastery!
Building Bridges to Reach People who Inject Drugs with the Goal of Employing PrEP for HIV Prevention
Strengthening Your Knowledge of Blood-Based Screening Tools
Bringing HIV Prevention to a New Level
Optimizing HIV Prevention in Primary Care
