Answers to Everyday Challenges in PrEP Practice
A Phone-a-Friend Series
Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.
Baeten JM, et al. N Engl J Med. 2012;367(5):399-410.
Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlled phase 3 trial.
Choopanya K, et al. Lancet. 2013;381(9883):2083-2090.
Emtricitabine/tenofovir alafenamide.
HIV.gov. Drug database.
Emtricitabine/tenofovir disoproxil fumarate.
HIV.gov. Drug database.
Cabotegravir.
HIV.gov. Drug database.
Lenacapavir.
HIV.gov. Drug database.
Being PrEPared—preexposure prophylaxis and HIV disparities.
Goldstein RH, et al. N Engl J Med. 2018;379(14):1293-1295.
Preexposure chemoprophylaxis for HIV prevention in men who have sex with men.
Grant RM, et al. N Engl J Med. 2010;363(27):2587-2599.
Lifetime risk of a diagnosis of HIV infection in the United States.
Hess KL, et al. Ann Epidemiol. 2017;27(4):238-243.
Cabotegravir for HIV prevention in cisgender men and transgender women.
Landovitz RJ, et al. N Engl J Med. 2021;385(7):595-608.
Cabotegravir for the prevention of HIV-1 in women: results from HPTN 084, a phase 3, randomised clinical trial.
Delany-Moretlwe S, et al. Lancet. 2022;399(10337):1779-1789.
Emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV pre-exposure prophylaxis (DISCOVER): primary results from a randomised, double-blind, multicentre, active-controlled, phase 3, non-inferiority trial.
Mayer KH, et al. Lancet. 2020;396(10246):239-254.
Twice-yearly lenacapavir or daily F/TAF for HIV prevention in cisgender women.
Bekker, et al. N Engl J Med. 2024;391(13):1179-1192.
Twice-yearly lenacapavir for HIV prevention in men and gender-diverse persons.
N Engl J Med. 2025;392(13):1261-1276.
PrEP Access, Assistance, and Information
Patient and Provider assistance: PleasePrEPMe.org.
Information about PrEP, nPEP, insurance and insurance rights, finding a PrEP/nPEP provider, and a list of PrEP resources by state
Provider assistance: AETC; AIDS Education & Training Center Program: National Coordinating Resource Center
Supports national HIV priorities by providing training, consultation, and resources
Patient assistance (without insurance).
The PrEP patient assistance program will provide medication at no cost for those who meet income guidelines.
Uninsured 24/7 support online, by phone during business hours and fax enrollment:
Copay assistance (for patients with nongovernment insurance).
Phone number: 1-800-226-2056
Copay assistance/out-of-pocket costs.
ViiV Connect.
Clinical Practice Guidelines
Preexposure prophylaxis for the prevention of HIV infection in the United States—2021 update: a clinical practice guideline.
US Public Health Service. Centers for Disease Control and Prevention; 2021.
Final Recommendation Statement. Prevention of Acquisition of HIV: Preexposure Prophylaxis.
U.S. Preventive Services Task Force. 2023.
Antiretroviral drugs for treatment and prevention of HIV in adults: 2024 recommendations of the International Antiviral Society-USA Panel.
Gandhi RT, et al. JAMA. 2025;333(7):609-628.
Preexposure prophylaxis for HIV: updated recommendations from the 2024 International Antiviral Society-USA Panel.
Landovitz RJ, et al. JAMA. 2025. Epub ahead of print.
Sexually transmitted infections treatment guidelines. 2021.
Centers for Disease Control and Prevention. Last reviewed July 2021.
CDC clinical guidelines on the use of doxycycline postexposure prophylaxis for bacterial sexually transmitted infection prevention, United States, 2024.
Bachmann LH, et al. MMWR Recomm Rep. 2024;73(2);1-8.
2018 quick reference guide: recommended laboratory HIV testing algorithm for serum or plasma specimens.
CDC Stacks. Centers for Disease Control and Prevention; last updated January 2018.
Antiretroviral postexposure prophylaxis after sexual, injection drug use, or other nonoccupational exposure to HIV - CDC recommendations, United States, 2025.
Tanner MR, et al. MMWR Recomm Rep. 2025;74(1):1-56.
The Fenway Guide to Lesbian, Gay, Bisexual, and Transgender Health.
Makadon H, et al, American College of Physicians (ACP), eds. 2nd ed. Boston, MA: Fenway Health; 2015.
National Institute of Allergy and Infectious Diseases HIV Language Guide, 2024.
Professional Organizations & Resources
HealthHIV.
HIV Prevention Certified Provider™ Certification Program.
American Academy of HIV Medicine.
HIV Nexus: CDC Resources for Clinicians.
Centers for Disease Control and Prevention.
National Clinician Consultation Center.
University of California, San Francisco; 2023.
HIV drug interactions.
University of Liverpool (website); updated October 2023.
Bright Futures Adolescence Tools.
American Academy of Pediatrics (website); updated May 2022.
HIV Public Health Partners: State HIV Prevention Profiles.
Centers for Disease Control and Prevention.
State Laws and Policies: Minors’ Access to STI Services; updated March 2025.
Guttmacher.
PrEP implementation checklists.
PrEPWatch.
Pre-Exposure Prophylaxis (PrEP), Post-Exposure Prophylaxis (PEP), and Other HIV Prevention Strategies Billing and Coding Guide; October 2023.
NASTAD.
Managing PrEP Regimen Changes to Meet Patient Lifestyle Needs
Module 1
| Faculty: | Jill Blumenthal, MD, MAS; Chase Cannon, MD |
| Release: | 08/30/2025 |
| Expiration: | 08/30/2026 |
