SM Challenge

Program Description

Start your morning with an immersive CME COMPETE™ activity, where education meets friendly competition. This interactive, case-based program energizes clinicians as they refine their approach to diagnosing and managing nonadvanced systemic mastocytosis (SM). Learners will navigate scenario-driven challenges that emphasize the importance of high-sensitivity molecular assays, accurate disease classification, and effective use of patient-reported outcomes. Expert faculty will guide teams through current therapeutic options, including approved targeted agents and late-stage investigational therapies shaping the evolving SM landscape. By earning points through data-driven decision-making, participants will strengthen their ability to individualize care and improve outcomes for patients living with nonadvanced SM. 

Target Audience

This activity is designed to educate a primary audience of allergy/immunology, dermatology, and related clinicians attending and interested in AAAAI.

Educational Objectives

Upon completion of this activity, the participant should be better able to: 

• Explain the pathophysiology of nonadvanced SM, including driver mutations, mast cell hyperactivation, and the scientific rationale for targeted therapy. 
• Apply updated diagnostic criteria (World Health Organization [WHO]/International Consensus Classification [ICC]) and integrate clinical cues, biomarkers, and genetic testing to improve timely and accurate diagnosis. 
• Summarize current and emerging therapies for nonadvanced SM, including trial evidence and FDA-approved targeted treatments. 
• Develop personalized treatment strategies that balance efficacy, safety, patient-reported outcomes, shared decision-making, and patient education, including trigger avoidance, anaphylaxis preparedness, and access to advocacy/resources.