Non-CME Corporate Forum sponsored by Blueprint Medicines and Cogent Biosciences.

Target Audience

The design of this activity addresses the needs of clinical immunologists, allergists, dermatologists, gastroenterologists and hematology/oncology clinicians and other healthcare professionals who manage patients with nonadvanced systemic mastocytosis (SM).

Program Overview

Nonadvanced SM is a rare, often misdiagnosed condition associated with high symptom burden and significant quality-of-life impact. This interactive program features a didactic overview of pathophysiology, diagnosis, and evolving treatment strategies of nonadvanced SM, followed by a fun and engaging Medical Jeopardy™-style game to reinforce key concepts.

Learning Objectives

After completing this activity, the participant should be better able to:

• Describe the biologic mechanisms underlying nonadvanced SM, including key driver mutations and mast cell activation pathways and how they form the basis for targeted therapies
• Differentiate nonadvanced subtypes using contemporary World Health Organization (WHO)/International Consensus Classification (ICC) diagnostic frameworks that integrate clinical features, biomarkers, and molecular testing to support earlier and more accurate diagnosis and classification
• Evaluate evidence for approved and emerging therapies for nonadvanced SM, including key clinical trial data, safety considerations, and appropriate patient selection
• Implement individualized management strategies for nonadvanced SM that incorporate therapeutic risk–benefit considerations, patient-reported outcomes, shared decision-making, and patient education

Disclosure of Unlabeled Use

This activity may contain discussion of published and/or investigational uses of agents that are not indicated by the US Food and Drug Administration. Integritas does not recommend the use of any agent outside of the labeled indications. The opinions expressed in the activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Prefer to participate in-person? Register for our live event at ExchangeCME.com/SMPhoenixLive.