Interactive Exchange

The Kidneys in Type 2 Diabetes: Disturbed Glucose Homeostasis to Mechanism-Based Therapy

Meeting Slides

Meeting Materials

Download slides presented at the ADA's 74th Scientific Session.


American Diabetes Association’s Standards of Medical Care in Diabetes—2014

The ADA’s Standards of Care provide clinicians, patients, researchers, payers, and other interested individuals with the components of good diabetes management, general treatment goals, and tools to evaluate the quality of care. Importantly, these recommendations should be adjusted based on individual preferences, comorbidities, and other patient-related factors.
American Diabetes Association. Diabetes Care. 2014;37(suppl 1):S14-S80.

American Association of Clinical Endocrinologists’ Comprehensive Diabetes Management Algorithm 2013

This algorithm from the AACE addresses evaluating the whole patient, potential risks and complications, and evidence-based treatment approaches for diabetes. The document contains sections on obesity, prediabetes, hyperglycemia therapy (lifestyle modifications, pharmacotherapy, and insulin), hypertension management, hyperlipidemia treatment, and other risk-reduction strategies.
Garber AJ, et al. Endocr Pract. 2013;19(suppl 1):1-48.

Kidney Disease Outcomes Quality Initiative Clinical Practice Guideline for Diabetes and Chronic Kidney Disease: 2012 Update

The 2012 update of the KDOQI Clinical Practice Guideline from the National Kidney Foundation can assist practitioners when caring for patients with diabetes who are at risk for or suffering from chronic kidney disease. This publication addresses appropriate hemoglobin A1c targets, lipid goals, and the use of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in patients with diabetes with and without albuminuria.
National Kidney Foundation. Am J Kidney Dis. 2012;60(5):850-886.


Diabetes HealthSense

Provides easy access to resources to help you live well and meet your goals—whether you have diabetes or are at risk for the disease.

7 Self-Care Behaviors Monitoring Form from the American Association of Diabetes Educators

The AADE developed the 7 Self-Care Behaviors Monitoring Form to provide a structure for tracking diet, physical activity, medication adherence, and overall lifestyle modifications.

Diabetes Health Sense Web site from the National Diabetes Education Program

The NDEP has collected and posted resources for patients living with T2DM online at the Diabetes Health Sense Web site. In addition to recommendations on lifestyle changes and medication use, patients will find a blood sugar and daily activity log that supports dietary improvements, increased physical activity, and other lifestyle changes.

Diabetes 24/7 Online Monitoring Tool from the American Diabetes Association

Diabetes 24/7 is a helpful online tool for monitoring and documenting blood sugar levels. Patient reporting promotes diabetes self-management and data can be shared with health care providers.

Suggested Readings

Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial

Bailey CJ, et al. Lancet. 2010;375(9733):2223-2233.

Effects of sodium-glucose co-transporter 2 inhibitors on blood pressure: A systematic review and meta-analysis

Baker WL, et al. J Am Soc Hypertens. 2014;8(4):262-275.

Sodium glucose co-transport 2 inhibitors in the treatment of type 2 diabetes mellitus: a meta-analysis of randomized double-blind controlled trials

Berhan A, Barker A. BMC Endocr Disord. 2013;13(1):58.

The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia

DeFronzo RA, et al. Diabetes Obes Metab. 2012;14(1):5-14.

Sodium–glucose linked transporter-2 inhibitors: potential for renoprotection beyond blood glucose lowering?

Gilbert RE. Kidney Int. 2013 Nov 20. [Epub ahead of print]

Management of hyperglycemia in type 2 diabetes: a patient-centered approach: Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Inzucchi SE, et al. Diabetes Care. 2012;35(6):1364-1379.

Clinical potential of sodium-glucose cotransporter 2 inhibitors in the management of type 2 diabetes

Kim Y, Babu AR. Diabetes Metab Syndr Obes. 2012;5:313-327.

SGLT-2 inhibitors and their potential in the treatment of diabetes

Rosenwasser RF, et al. Diabetes Metab Syndr Obes. 2013;6:453-467.

Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise

Stenlöf K, et al. Diabetes Obes Metab. 2013;15(4):372-382.

Dapagliflozin in patients with type 2 diabetes receiving high doses of insulin: efficacy and safety over 2 years

Wilding JPH, et al. Diabetes Obes Metab. 2014;16(2)124-136.

Interactive Presentation

Scientific Insights Into the Kidneys and Glucose Homeostasis

Daniel Einhorn, MD, FACE, FACP

The Kidneys in Type 2 Diabetes

Disturbed Glucose Homeostasis to Mechanism-Based Therapy

Relevant Resources

Incretin-Based Therapies for Type 2 Diabetes

Mechanism-Based Strategies to Achieve Patient-Centered Care

Insulin Replacement Therapy for Type 2 Diabetes

Patient-Centered Management of Hyperglycemia in Primary Care

Improving Outcomes in Type 2 Diabetes

Integrating GLP-1 Receptor Agonists Into Multimodal Treatment Regimens

A Focus on Bipolar Depression

Overcoming Diagnostic Barriers and Optimizing Long-Term Patient Outcomes

Clinical Issues in Type 2 Diabetes

Discussions and Debates Around GLP-1 Receptor Agonists

Clinical Issues in Type 2 Diabetes

Evolving Roles of GLP-1 Receptor Agonists

Improving Outcomes for Women with Type 2 Diabetes

Individualizing Evidence-Based Care

Noninsulin Approaches to Managing Type 2 Diabetes

Best Practices in Combination Therapy

Hitting the Target in Type 2 Diabetes

Evolving Approaches to Insulin Based Therapy

Improving Outcomes in Congenital and Acquired Lipodystrophy

Best Practices in Diagnosis and Management

Clinical Updates in Type 2 Diabetes

New Strategies for Insulin Replacement Therapy

Clinical Issues in Type 2 Diabetes

Consensus and Controversies Around Intensifying Noninsulin Therapy

How Low Do You Go?

Clinical Updates in LDL-C Management

Incretin-Based Therapies For Type 2 Diabetes

Improving Comprehensive Patient Care

Clinical Updates in Type 2 Diabetes

An Evolving Role for Combinations of Injectable Antihyperglycemic Therapies

Raising the Bar by Lowering the Target

Integrating PCSK9 Inhibitors Into Hypercholesterolemia Management

Injecting New Ideas into Managing Type 2 Diabetes

Evolving Roles of GLP-1 Receptor Agonists

Multidimensional Issues in Type 2 Diabetes

Looking Beyond Hemoglobin A1c

GLP-1 Receptors Agonists in Type 2 Diabetes

Mechanistic Insights and Evolving Treatment Options

Pharmaceutical Economics and LDL-C Management

Implications for PCSK9 Inhibitors in Clinical Practice

Assimilating the Evidence in T2DM

Cardiovascular and Renal Outcomes With SGLT2 Inhibitors

Getting Low in Familial Hypercholesterolemia

Reducing LDL-C and a Lifetime of Cardiovascular Risk

Making the Call in Heart Failure

Multidimensional Outcomes With SGLT2 Inhibitors

Anemia in Chronic Kidney Disease

New Avenues to Improve Patient Outcomes