Clinical Issues™

Clinical Issues in Atopic Dermatitis

Discussions and Debates About Moderate-to-Severe Disease

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Clinical Practice Guidelines

Guidelines for Treatment of atopic eczema (atopic dermatitis): part 1. 

Ring J, et al. J Eur Acad Dermatol Venereol. 2012;26(8):1045-1060.

Guidelines for Treatment of atopic eczema (atopic dermatitis): part 2. 

Ring J, et al. J Eur Acad Dermatol Venereol. 2012;26(8):1176-1193.

Guidelines of care for the management of atopic dermatitis: part 3. Management and treatment with phototherapy and systemic agents.

Sidbury R, et al. J Am Acad Dermatol. 2014;71(2):327-349.

Guidelines of care for the management of atopic dermatitis: part 4. Prevention of disease flares and use of adjunctive therapies and approaches.

Sidbury R, et al. J Am Acad Dermatol. 2014;71(6):1218-1233.

Patient Resources

International Eczema Council

Founded in late 2014, the International Eczema Council (IEC) is a global nonprofit organization led by dermatology experts on atopic dermatitis. The IEC is dedicated to increasing the understanding of atopic dermatitis and promoting its optimal management through research, education, and patient/family care.

National Eczema Association

The National Eczema Association is a nonprofit organization founded in 1988 to improve the health and quality of life for individuals with eczema through research, support, and education.

Clinical Assessment Tools

Eczema Area and Severity Index (EASI)

EASI is a clinician assessment tool designed to measure clinical severity of atopic dermatitis. Severity scores can range from 0 (clear) to 72 (very severe). (Hanifin JM, et al. Exp Dermatol. 2001;10(1):11-18).

Investigator Global Assessment (IGA)

The IGA is a clinician assessment strategy designed to provide a snapshot of overall disease severity in dermatologic clinical trials. (Futamura M, et al. J Am Acad Dermatol. 2016;74(2):288-294).

Patient-Oriented Eczema Measure (POEM)

The POEM is a patient-administered measurement tool designed to assess occurence and frequency of atopic dermatitis symptoms during the previous week through a simple 5-point scale, with a maximum total score of 28. (Charman CR, et al. Arch Dermatol. 2004;140(12):1513-1519).

Scoring Atopic Dermatitis (SCORAD)

SCORAD is a clinical tool used to assess the extent and severity of eczema. (Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis. Dermatology. 1993;186(1):23-31.)

Suggested Readings

American Academy of Dermatology 75th Annual Meeting Posters. March 3-7, 2017. Orlando, Florida.

Management of difficult-to-treat atopic dermatitis.

Arkwright PD, et al. J Allergy Clin Immunol Pract. 2013;1(2):142-151

Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial.

Blauvelt A, et al. Lancet. 2017;389(10086):2287-2303.

Dupilumab with concomitant topical corticosteroids in adult patients with atopic dermatitis who are not adequately controlled with or are intolerant to ciclosporin A, or when this treatment is medically inadvisable: a placebo-controlled, randomized phase 3 clinical trial (LIBERTY AD CAFÉ).

de Bruin-Weller M, et al. Br J Dermatol. 2018;178(5):1083-1101. 

Use of systemic corticosteroids for atopic dermatitis: International Eczema Council consensus statement.

Drucker AM, et al. Br J Dermatol. 2018;178(3):768-775.

Translating atopic dermatitis management guidelines into practice for primary care providers.

Eichenfield LF, et al. Pediatrics. 2015;136(3):554-565.

Persistence of mild to moderate atopic dermatitis.

Margolis JS, et al. JAMA Dermatol. 2014;150(6):593-600.

Association between atopic dermatitis and serious cutaneous, multiorgan and systemic infections in US adults.

Narla S, Silverberg JI. Ann Allergy Asthma Immunol. 2018;120(1):66-72.

Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults.

Paller AS, et al. J Am Acad Dermatol. 2016;75(3):494-503.

Serious complications from staphylococcal aureus in atopic dermatitis.

Patel D, Jahnke MN. Ped Dermatol. 2015;32(6):792-796.

Anti-interleukin-31 receptor A antibody for atopic dermatitis.

Ruzicka T, et al. N Engl J Med. 2017;376(9):826-835.

Patient burden of moderate to severe atopic dermatitis (AD): insights from a phase 2b clinical trial of dupilumab in adults.

Simpson EL, et al. J Am Acad Dermatol. 2016;74(3):491-498.

Efficacy and safety of lebrikizumab (an anti-IL-13 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical corticosteroids: A randomized, placebo-controlled phase II trial (TREBLE).

Simpson EL, et al. J Am Acad Dermatol. 2018;78(5):863-871.

Two phase 3 trials of dupilumab versus placebo in atopic dermatitis.

Simpson EL, et al. N Engl J Med. 2016;375(24):2335-2348.

Eczema and cardiovascular risk factors in 2 US adult population studies.

Silverberg JI, Greenland P. J Allergy Clin Immunol. 2015;135(3):721-728.

New therapies for atopic dermatitis: Additional treatment classes.

Vakharia PP, Silverberg JI. J Am Acad Dermatol. 2018;78(3S1):S76-S83.

The burden of atopic dermatitis in US adults: results from the 2013 National Health and Wellness Survey.

Whiteley J, et al. Curr Med Res Opin. 2016;32(10):1645-1651.

Interactive Presentation

Clinical Insights Into Atopic Dermatitis Pathogenesis

Narrated by Jeffrey M.Weinberg, MD

Patient Interview

With Amanda

Patient Interview

With Sanjeev

Clinical Issues in Atopic Dermatitis

Discussions and Debates About Managing Moderate-to-Severe Disease

Clinical Issues in Atopic Dermatitis

Debates and Discussions About Managing Moderate-to-Severe Disease

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