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Evidence-Based Best-Practices

A Focus on Bipolar Depression

Overcoming Diagnostic Barriers and Optimizing Long-Term Patient Outcomes

Meeting Slides

Clinical Tools

Mood Disorder Questionnaire

A commonly used, sensitive, and specific screening questionnaire for bipolar disorder. A score of 7 or more across three criteria suggests the presence of bipolar disorder (Hirschfeld RM, et al. Am J Psychiatry. 2000;157(1):1873-1875).

Quick Inventory of Depressive Symptomatology—Self Report

A 16-item self-report assessment of 9 DSM-IV symptom criteria for major depressive disorder. Patients rate items as not present, mild, moderate, or severe with scores ranging from 0 to 27 (0-5, no depression; 6-10, mild depression; 11-15, moderate depression; 16-20, severe depression; >20, very severe depression) (Berk M, et al. Bipolar Disord. 2007;9(6):571-579).

Guidelines

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: 2013 update.

Yatham LN, et al. Bipolar Disord. 2013;15(1):1-44.

VA/DoD Clinical Practice Guideline for Management of Bipolar Disorder in Adults

Department of Veterans Affairs, Department of Defense. Clinical Practice Guideline for Management of Bipolar Disorder in Adults. Washington, DC: Department of Veterans Affairs, Department of Defense; 2010.

Diagnostic and Statistical Manual of Mental Disorders (Fifth edition)

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (Fifth edition). Arlington, VA: American Psychiatric Publishing; 2013.

Other Resources

Depression and Bipolar Support Alliance

The Depression and Bipolar Support Alliance (DBSA) offers resources for patients, materials for clinicians, information on mental health research as well as listings to patient support groups across the United States.

Suggested Readings

Clinical differences between bipolar and unipolar depression

Forty L, et al. Br J Psychiatry. 2008;19(5):388-389.

Strategies for monitoring outcomes in patients with bipolar disorder

Ketter TA. Prim Care Companion J Clin Psychiatry. 2010;12(suppl 1):10-16.

Lurasidone monotherapy in the treatment of bipolar I depression: a randomized, double-blind, placebo-controlled study

Loebel A, et al. Am J Psychiatry. 2014;171(2):160-168.

Lurasidone as adjunctive therapy with lithium or valproate for the treatment of bipolar I depression: a randomized, double-blind, placebo-controlled study

Loebel A, et al. Am J Psychiatry. 2014;171(2):169-177.

The Canadian Network for Mood and Anxiety Treatments (CANMAT) task force recommendations for the management of patients with mood disorders and comorbid metabolic disorders

McIntyre RS, et al. Ann Clin Psychiatry. 2012;24(1):69-81.

The Canadian Network for Mood and Anxiety Treatments (CANMAT) task force recommendations for the management of patients with mood disorders and comorbid medical conditions: Diagnostic, assessment, and treatment principles

Ramasubbu R, et al. Ann Clin Psychiatry. 2012;24(1):82-90.

The Canadian Network for Mood and Anxiety Treatments (CANMAT) task force recommendations for the management of patients with mood disorders and select comorbid medical conditions

Ramasubbu R, et al. Ann Clin Psychiatry. 2012;24(1):91-109.

The neurobiology of the switch process in bipolar disorder: a review

Salvadore G, et al. J Clin Psychiatry 2010;71:1488-1501.

The functional neuroanatomy of bipolar disorder: a consensus model

Strakowski SM, et al. Bipolar Disord. 2012;14(4):313-325.

Efficacy of quetiapine monotherapy in bipolar I and II depression: a double-blind, placebo-controlled study (the BOLDER II study)

Thase ME, et al. J Clin Psychopharmacol. 2006;26(6):600-609.

Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression

Tohen M, et al. Arch Gen Psychiatry. 2003;60(11):1079-1088.

Metabolic syndrome in bipolar disorder: a review with a focus on bipolar depression.

McElroy SL, Keck PE. J Clin Psychiatry. 2014;75(1):46-61.

Interactive Presentation

Scientific Insights Into Bipolar Disorder

Michael E. Thase, MD


Relevant Resources

Incretin-Based Therapies for Type 2 Diabetes

Mechanism-Based Strategies to Achieve Patient-Centered Care

Reducing the Burden of Bipolar Depression

Improved Diagnostic and Management Strategies

Insulin Replacement Therapy for Type 2 Diabetes

Patient-Centered Management of Hyperglycemia in Primary Care

Improving Outcomes in Type 2 Diabetes

Integrating GLP-1 Receptor Agonists Into Multimodal Treatment Regimens

Improving Outcomes in Bipolar Depression

Overcoming Diagnostic Challenges, Targeting Remission, and Optimizing Cardiometabolic Health

Comprehensive Management of Bipolar Depression

New Approaches to Optimizing Patient Outcomes

Multidisciplinary Management of Bipolar Disorder

Accelerating Diagnosis, Achieving Remission, and Encouraging Adherence

Clinical Issues in Type 2 Diabetes

Discussions and Debates Around GLP-1 Receptor Agonists

Clinical Issues in Type 2 Diabetes

Evolving Roles of GLP-1 Receptor Agonists

Improving Outcomes for Women with Type 2 Diabetes

Individualizing Evidence-Based Care

Mixed Features in Depressive Episodes

Managing Patients Across the Disease Spectrum

Noninsulin Approaches to Managing Type 2 Diabetes

Best Practices in Combination Therapy

Hitting the Target in Type 2 Diabetes

Evolving Approaches to Insulin Based Therapy

Agitation and Psychiatric Disease

Best Practices for Emergency Care

Improving Outcomes in Congenital and Acquired Lipodystrophy

Best Practices in Diagnosis and Management

Clinical Updates in Type 2 Diabetes

New Strategies for Insulin Replacement Therapy

Clinical Issues in Type 2 Diabetes

Consensus and Controversies Around Intensifying Noninsulin Therapy

How Low Do You Go?

Clinical Updates in LDL-C Management

Incretin-Based Therapies For Type 2 Diabetes

Improving Comprehensive Patient Care

Clinical Issues in Bipolar Depression

Consensus and Controversies Across the Spectrum of Patient Presentations

Clinical Updates in Type 2 Diabetes

An Evolving Role for Combinations of Injectable Antihyperglycemic Therapies

Raising the Bar by Lowering the Target

Integrating PCSK9 Inhibitors Into Hypercholesterolemia Management

Injecting New Ideas into Managing Type 2 Diabetes

Evolving Roles of GLP-1 Receptor Agonists