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Clinical Research Updates

Improving Outcomes in Congenital and Acquired Lipodystrophy

Best Practices in Diagnosis and Management

Guidelines

The Clinical Approach to the Detection of Lipodystrophy—A Consensus Statement From the American Association of Clinical Endocrinologists

A consensus statement from the American Academy of Clinical Endocrinologists about the classification, detection, and diagnosis of various types of lipodystrophy. The expert task force of clinical practitioners and leaders in lipodystrophy research aims to increase awareness of these underdiagnosed disorders and provide a framework for future diagnostic criteria.
Handelsman Y, et al. Endocr Pract. 2013;19(1):107-116.

Online Resources

Lipodystrophy Resource Center at The Endocrine Society

The Endocrine Society has created a variety of educational materials covering the pathophysiology, clinical presentations, and treatment of lipodystrophies. Particular emphasis is placed on the connections between generalized or partial adipose tissue loss and their often severe metabolic complications, including severe insulin resistance, type 2 diabetes, and hypertriglyceridemia.

Lipodystrophy United Website

Lipodystrophy United is an organization of committed individuals living strong with Lipodystrophy. Our mission is to provide an interactive community, facilitating support and education for anyone affected by this rare disease. We serve as a resource and to increase awareness in the general population as well as the medical and insurance communities. We advocate and act as a catalyst for new patient diagnosis by assisting healthcare professionals in the understanding of Lipodystrophy trends, physical attributes and clinical symptoms in order to aid in the advancement of knowledge, treatment and future research.

Lipodystrophy Connect Regisrty

Registry stores detailed information in one place making it easier for researchers to share and study information, while still protecting the privacy of those who take part. This research is being done to better understand LD, and to answer questions such as how LD is treated, and what can be done to improve care for people with LD.

Suggested Readings

Clinical classification and treatment of congenital and acquired lipodystrophy.

Chan JL, Oral EA. Endocr Pract. 2010;16(2):310-323.

Clinical effects of long-term metreleptin treatment in patients with lipodystrophy.

Chan JL, et al. Endocr Pract. 2011;17(6):922-932.

Ectopic lipid storage and insulin resistance: a harmful relationship.

Borén J, et al. J Intern Med. 2013;274(1):25-40.

Exploring the pathophysiology behind the more common genetic and acquired lipodystrophies.

Nolis T. J Hum Genet. 2014;59(1):16-23.

How to diagnose a lipodystrophy syndrome.

Vantyghem MC, et al. Ann Endocrinol (Paris). 2012;73(3):170-189.

Lipodystrophy: pathophysiology and advances in treatment.

Fiorenza CG, et al. Nat Rev Endocrinol. 2011;7(3):137-150.

Lipodystrophies: genetic and acquired body fat disorders.

Garg A. J Clin Endocrinol Metab. 2011;96(11):3313-3325.

Lipodystrophy: metabolic insights from a rare disorder.

Huang-Doran I, et al. J Endocrinol. 2010;207(3):245-255.

Leptin and the central nervous system control of glucose metabolism.

Morton GJ, Schwartz MW. Physiol Rev. 2011;91(2):389-411.

New advances in the treatment of generalized lipodystrophy: role of metreleptin.

Rodriguez AJ, et al. Ther Clin Risk Manag. 2015;11(1):1391-1400

Rationale for leptin-replacement therapy for severe lipodystrophy.

Oral EA, Chan JL. Endocr Pract. 2010;16(2):324-333.

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Improving Outcomes in Congenital and Acquired Lipodystrophy

Best Practices in Diagnosis and Management

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