Clinical Issues™

Clinical Issues in Chronic Pain

Debates and Discussions About Therapeutically Targeting Nerve Growth Factor Signaling

Meeting Slides

Clinical Practice Guidelines

Chronic opioid therapy for chronic non-cancer pain: a review and comparison of treatment guidelines.

Cheung CW, et al. Pain Physician. 2014;17(5):401-414.

CDC guideline for prescribing opioids for chronic pain—United States, 2016.

Dowell D, et al. JAMA. 2016;315(15):1624-1645.

Patient Resources

American Chronic Pain Association

Information about conditions, management tools, advocacy, and support.

Centers for Disease Control and Prevention

Educational materials for patients about chronic pain and taking opioids.

International Association for the Study of Pain

List of local and national organizations dedicated to pain management, as well as a library of videos and articles for patient support.

U.S. Pain Foundation

Source for education, support, and advocacy for patients living with pain.

Clinical Assessment Tools

Pain BC

Collection of assessment tools to measure pain, pain-related anxiety, pain-related depression, and pain outcomes.

Pain Disability Index

Assess level of disruption in daily life caused by chronic pain.

Roland Morris Disability Questionnaire

Questionnaire to assess low back pain.

WOMAC Osteoarthritis Index

Scale to assess both knee and hip osteoarthritis pain.

Suggested Readings

Safety and efficacy of subcutaneous tanezumab in patients with knee or hip osteoarthritis.

Birbara C, et al. J Pain Res. 2018;11:151-164.

Nerve growth factor and pain mechanisms.

Denk F, et al. Annu Rev Neurosci. 2017;40:307-325.

Relieving pain in America: a blueprint for transforming prevention, care, education, and research.

Institute of Medicine. Washington, DC: National Academies Press (US); 2011.

Efficacy and safety of tanezumab versus naproxen in the treatment of chronic low back pain.

Kivitz AJ, et al. Pain. 2013;154(7):1009-1021.

NGF—the TrkA to successful pain treatment.

Kumar V, Mahal BA. J Pain Res. 2012;5:279-287.

Emerging targets for the management of osteoarthritis pain.

Malfait AM, Miller RJ. Curr Osteoporos Rep. 2016;14(6):260-268.

Current status of nerve growth factor antibodies for the treatment of osteoarthritis pain.

Miller RE, et al. Clin Exp Rheumatol. 2017;35 (suppl 107[5]):85-87.

The discriminative validity of “nociceptive,” “peripheral neuropathic,” and “central sensitization” as mechanisms-based classifications of musculoskeletal pain.

Smart KM, et al. Clin J Pain. 2011;27(8):655-663.

Fasinumab (REGN475), an antibody against nerve growth factor for the treatment of pain: results from a double-blind, placebo-controlled exploratory study in osteoarthritis of the knee.

Tiseo PJ, et al. Pain. 2014;155(7):1245-1252.

What is this thing called pain?

Woolf CJ. J Clin Invest. 2010;120(11):3742-3744.

Interactive Presentation

NGF Pathophysiology

Charles E. Argoff, MD

Clinical Issues in Chronic Pain

Debates and Discussions About Therapeutically Targeting Nerve Growth Factor Signaling

Intrathecal Therapy for Severe Chronic Pain: Evidence-Based Recommendations

Module 1

Practical Recommendations and Demonstrations

Module 2

Relevant Resources

Persistent and Breakthrough Pain

Balancing the Benefits and Risk of Opioid-Based Therapy

Improving the Care of Patients With Chronic Pain

Individualized Assessment and Mechanism-Based Multimodal Treatment

Caring For Patients With Chronic Pain

Responsible Opioid Prescribing to Achieve Individualized Functional Goals

Acute Management of Migraine Attacks

Overcoming Pain and Gastrointestinal Distress to Improve Patient Outcomes

Opioid-Induced Constipation

Proactive Diagnosis and Targeted Management

Intrathecal Drug Delivery for Chronic Pain

Selecting Patients and Optimizing Long-Term Outcomes

Opioid-Induced Constipation

Proactive Diagnosis and Targeted Management

Clinical Issues in Chronic Pain

Consensus and Controversies for Responsible Opioid Prescribing

Intrathecal Drug Delivery for Chronic Pain

The Role of Nurses in Optimizing Long-term Outcomes

Intrathecal Drug Therapy for Chronic Pain

Evolving Best-Practice Strategies to Maximize Efficacy and Safety

Comprehensive Chronic Pain Management

A Focus on Patients With Opioid-Induced Constipation

Best Practices in Intrathecal Therapy for Chronic Pain

Patient Selection, Treatment Initiation, and Ongoing Monitoring

Overcoming Challenges in Cancer Pain Management

Engaging With Patients About Opioid-Induced Constipation

Can You Spot Axial Spondyloarthritis?

The PCP’s Role in Timely Recognition and Referral

Comprehensive Relief from Cancer Pain

Expanding the Conversation on Opioid-Induced Constipation

Managing Opioid-Induced Constipation

Translating Guidelines Into Patient Care

Finding Relief in Osteoarthritis

New Paths to Chronic Pain Management

What’s New in Systemic Lupus Erythematosus?

Unlocking Novel Paths to Patient Care

Maybe It’s NOT Mechanical Back Pain

Getting on the Fast Track to Identify AxSpA