Opioid-Induced ConstipationProactive Diagnosis and Targeted Management
Opioid-induced bowel dysfunction: epidemiology, pathophysiology, diagnosis, and initial therapeutic approach.
Dorn S, et al. Am J Gastroenterol. 2014;2(1):31-37.
Opioid-induced constipation in patients with chronic noncancer pain in the USA, Canada, Germany, and the UK: descriptive analysis of baseline patient-reported outcomes and retrospective chart review.
Coyne KS, et al. Clinicoecon Outcomes Res. 2014;6:269-281.
Ahmedzai SH, Boland J. BMJ Clin Evid (Online). 2010;pii:2407
Drossman D, Szigethy E. Am J Gastroenterol. 2014;2(1):22-30.
Kalso E, et al. Pain. 2004;112(3):372-380.
A multi-institutional study analyzing effect of prophylactic medication for prevention of opioid-induced gastrointestinal dysfunction.
Ishihara M, et al. Clin J Pain. 2012;28(5):373-381.
Sykes NP. J Pain Symptom Manage. 1996;11(6):363-369.
Fine PG, et al. J Pain Symptom Manage. 2009;38(3):418-425.
Chey WD, et al. N Engl J Med. 2014;370(25):2387-2396.
A randomized study of lubiprostone for opioid-induced constipation in patients with chronic noncancer pain.
Cryer B, et al. Pain Med. 2014; 15(11):1825-1834.
Clinical evaluation of the efficacy of methylnaltrexone in resolving constipation induced by different opioid subtypes combined with laboratory analysis of immunomodulatory and antiangiogenic effects of methylnaltrexone.
Neefjes ECW, et al. BMC Palliative Care. 2014;13:42.
Patient preference with respect to QoL and reduction in opioid-induced constipation (OIC) after treatment with prolonged-release (PR) oxycodone/naloxone compared with previous analgesic therapy [PREFER study].
van Dongen VCPC, et al. Int J Clin Pract. 2014;68(11):1364-1375.
Scientific Insights Into Opioid-Induced Constipation
Anthony J. Lembo, MD
Balancing the Benefits and Risk of Opioid-Based Therapy
Individualized Assessment and Mechanism-Based Multimodal Treatment
Responsible Opioid Prescribing to Achieve Individualized Functional Goals
Overcoming Pain and Gastrointestinal Distress to Improve Patient Outcomes
Selecting Patients and Optimizing Long-Term Outcomes
Proactive Diagnosis and Targeted Management
Consensus and Controversies for Responsible Opioid Prescribing
The Role of Nurses in Optimizing Long-term Outcomes
Evolving Best-Practice Strategies to Maximize Efficacy and Safety
A Focus on Patients With Opioid-Induced Constipation
Patient Selection, Treatment Initiation, and Ongoing Monitoring
Engaging With Patients About Opioid-Induced Constipation
The PCP’s Role in Timely Recognition and Referral
Debates and Discussions About Therapeutically Targeting Nerve Growth Factor Signaling
Expanding the Conversation on Opioid-Induced Constipation