Eloralintide, a selective amylin receptor agonist for the treatment of obesity: a 48-week phase 2, multicentre, double-blind, randomised, placebo-controlled trial
Billings LK, Hsia S, Bays H, et al. Lancet. 2025;406(10520):2631-2643.
Amycretin, a novel, unimolecular GLP-1 and amylin receptor agonist administered subcutaneously: results from a phase 1b/2a randomised controlled study
Dahl K, Toubro S, Dey S, Duque do Vale R, Flint A, Gasoriek A. Lancet. 2025;406(10499):149-162.
Cagrilintide-semaglutide in adults with overweight or obesity and type 2 diabetes
Davies MJ, Bajaj HS, Broholm C, et al; REDEFINE 2 Study Group. N Engl J Med. 2025;393(7):648-659.
Coadministered cagrilintide and semaglutide in adults with overweight or obesity
Garvey WT, Blüher M, Osorto Contreras CK, et al; REDEFINE 1 Study Group. N Engl J Med. 2025;393(7):635-647.
Safety, tolerability, pharmacokinetics, and pharmacodynamics of the first-in-class GLP-1 and amylin receptor agonist, amycretin: a first-in-human, phase 1, double-blind, randomised, placebo-controlled trial
Gasiorek A, Heydorn A, Gabery S, et al. Lancet. 2025;406(10499):135-148.
Amylin: pharmacology, physiology, and clinical potential
Hay DL, Chen S, Lutz TA, Parkes DG, Roth JD. Pharmacol Rev. 2015;67(3):564-600.
Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial
Lau DCW, Erichsen L, Francisco AM, et al. Lancet. 2021;398(10317):2160-2172.
Amylin: from mode of action to future clinical potential in diabetes and obesity
Volčanšek Š, Koceva A, Jensterle M, Janež A, Muzurović E. Diabetes Ther. 2025;16(6):1207-1227.
Amylin: emergent therapeutic opportunities in overweight, obesity and diabetes mellitus
Walker CS, Aitken JF, Amarsingh GV, et al. Nat Rev Endocrinol. 2025;21(8):482-494.
Amylin-Based Therapies in Obesity Management
Top 10 Clinician Questions Answered
| Faculty: | Domenica M. Rubino, MD |
| Release: | 08/17/2026 |
| Expiration: | 08/17/2027 |
